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Amber Park, PhD
Research Associate 2015-2016 Cystic Fibrosis Canada Kin Fellow Amber studies the process of biofilm formation by the opportunistic pathogen Pseudomonas aeruginosa. Her project examines how environmental factors, host determinants, and strain-related differences impact this fundamental process, which contributes to bacterial pathogenesis, persistence, and antimicrobial resistance. Amber is using a multidisciplinary approach that combines molecular microbiology, cell culture, microscopy, and proteomics. Amber is the recipient of a research fellowship from Cystic Fibrosis Canada. |
Amber's Publications
Imaging host-pathogen interactions using epithelial and bacterial cell infection models.
Park AJ, Wright MA, Roach EJ, Khursigara CM. J Cell Sci. 2021 Feb 23;134(5)
SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.
Di Paola M*, Park AJ*, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM. MBio. 2017 Dec 19;8(6).
*Co-authors.
Potentiation of Tobramycin by Silver Nanoparticles against Pseudomonas aeruginosa Biofilms.
Habash MB, Goodyear MC, Park AJ, Surette MD, Vis EC, Harris RJ, Khursigara CM. Antimicrob Agents Chemother. 2017 Oct 24;61(11).
Survival Proteomes: The Emerging Proteotype of Antimicrobial Resistance.
Park AJ, Krieger JR, Khursigara CM. FEMS Microbiol Rev. 2016 May;40(3):323-42.
Tracking the Dynamic Relationship between Cellular Systems and Extracellular Subproteomes in Pseudomonas aeruginosa Biofilms.
Park AJ, Murphy K, Surette MD, Bandoro C, Krieger JR, Taylor P, Khursigara CM. J Proteome Res. 2015 Nov 6;14(11):4524-37.
Microbiota and Host Determinants of Behavioural Phenotype in Maternally Separated Mice.
De Palma G, Blennerhassett P, Lu J, Deng Y, Park AJ, Green W, Denou E, Silva MA, Santacruz A, Sanz Y, Surette MG, Verdu EF, Collins SM, Bercik P. Nat Commun. 2015 Jul 28;6:7735.
Antimicrobial Targets Localize to the Extracellular Vesicle-Associated Proteome of Pseudomonas aeruginosa Grown in a Biofilm.
Park AJ, Surette MD, Khursigara CM. Front Microbiol. 2014 Sep 3;5:464.
Synergy of Silver Nanoparticles and Aztreonam Against Pseudomonas aeruginosa PAO1 Biofilms.
Habash MB, Park AJ, Vis EC, Harris RJ, Khursigara CM. Antimicrob Agents Chemother. 2014 Oct;58(10):5818-30.
A Temporal Examination of the Planktonic and Biofilm Proteome of Whole Cell Pseudomonas aeruginosa PAO1 Using Quantitative Mass Spectrometry.
Park AJ, Murphy K, Krieger JR, Brewer D, Taylor P, Habash M, Khursigara CM. Mol Cell Proteomics. 2014 Apr;13(4):1095-105.
Influence of O polysaccharides on Biofilm Development and Outer Membrane Vesicle Biogenesis in Pseudomonas aeruginosa PAO1.
Murphy K, Park AJ, Hao Y, Brewer D, Lam JS, Khursigara CM. J Bacteriol. 2014 Apr;196(7):1306-17.
Altered Colonic Function and Microbiota Profile in a Mouse Model of Chronic Depression.
Park AJ, Collins J, Blennerhassett PA, Ghia JE, Verdu EF, Bercik P, Collins SM. Neurogastroenterol Motil. 2013 Sep;25(9):733-e575.
The Anxiolytic Effect of Bifidobacterium longum NCC3001 Involves Vagal Pathways for Gut-Brain Communication.
Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, Huang X, Deng Y, Blennerhassett PA, Fahnestock M, Moine D, Berger B, Huizinga JD, Kunze W, McLean PG, Bergonzelli GE, Collins SM, Verdu EF. Neurogastroenterol Motil. 2011 Dec;23(12):1132-9.
Adoptive Transfer of Macrophage From Mice With Depression-Like Behavior Enhances Susceptibility to Colitis.
Ghia JE, Park AJ, Blennerhassett P, Khan WI, Collins SM. Inflamm Bowel Dis. 2011 Jul;17(7):1474-89.
Imaging host-pathogen interactions using epithelial and bacterial cell infection models.
Park AJ, Wright MA, Roach EJ, Khursigara CM. J Cell Sci. 2021 Feb 23;134(5)
SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.
Di Paola M*, Park AJ*, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM. MBio. 2017 Dec 19;8(6).
*Co-authors.
Potentiation of Tobramycin by Silver Nanoparticles against Pseudomonas aeruginosa Biofilms.
Habash MB, Goodyear MC, Park AJ, Surette MD, Vis EC, Harris RJ, Khursigara CM. Antimicrob Agents Chemother. 2017 Oct 24;61(11).
Survival Proteomes: The Emerging Proteotype of Antimicrobial Resistance.
Park AJ, Krieger JR, Khursigara CM. FEMS Microbiol Rev. 2016 May;40(3):323-42.
Tracking the Dynamic Relationship between Cellular Systems and Extracellular Subproteomes in Pseudomonas aeruginosa Biofilms.
Park AJ, Murphy K, Surette MD, Bandoro C, Krieger JR, Taylor P, Khursigara CM. J Proteome Res. 2015 Nov 6;14(11):4524-37.
Microbiota and Host Determinants of Behavioural Phenotype in Maternally Separated Mice.
De Palma G, Blennerhassett P, Lu J, Deng Y, Park AJ, Green W, Denou E, Silva MA, Santacruz A, Sanz Y, Surette MG, Verdu EF, Collins SM, Bercik P. Nat Commun. 2015 Jul 28;6:7735.
Antimicrobial Targets Localize to the Extracellular Vesicle-Associated Proteome of Pseudomonas aeruginosa Grown in a Biofilm.
Park AJ, Surette MD, Khursigara CM. Front Microbiol. 2014 Sep 3;5:464.
Synergy of Silver Nanoparticles and Aztreonam Against Pseudomonas aeruginosa PAO1 Biofilms.
Habash MB, Park AJ, Vis EC, Harris RJ, Khursigara CM. Antimicrob Agents Chemother. 2014 Oct;58(10):5818-30.
A Temporal Examination of the Planktonic and Biofilm Proteome of Whole Cell Pseudomonas aeruginosa PAO1 Using Quantitative Mass Spectrometry.
Park AJ, Murphy K, Krieger JR, Brewer D, Taylor P, Habash M, Khursigara CM. Mol Cell Proteomics. 2014 Apr;13(4):1095-105.
Influence of O polysaccharides on Biofilm Development and Outer Membrane Vesicle Biogenesis in Pseudomonas aeruginosa PAO1.
Murphy K, Park AJ, Hao Y, Brewer D, Lam JS, Khursigara CM. J Bacteriol. 2014 Apr;196(7):1306-17.
Altered Colonic Function and Microbiota Profile in a Mouse Model of Chronic Depression.
Park AJ, Collins J, Blennerhassett PA, Ghia JE, Verdu EF, Bercik P, Collins SM. Neurogastroenterol Motil. 2013 Sep;25(9):733-e575.
The Anxiolytic Effect of Bifidobacterium longum NCC3001 Involves Vagal Pathways for Gut-Brain Communication.
Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, Huang X, Deng Y, Blennerhassett PA, Fahnestock M, Moine D, Berger B, Huizinga JD, Kunze W, McLean PG, Bergonzelli GE, Collins SM, Verdu EF. Neurogastroenterol Motil. 2011 Dec;23(12):1132-9.
Adoptive Transfer of Macrophage From Mice With Depression-Like Behavior Enhances Susceptibility to Colitis.
Ghia JE, Park AJ, Blennerhassett P, Khan WI, Collins SM. Inflamm Bowel Dis. 2011 Jul;17(7):1474-89.