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Elyse Roach, PhD
Elyse completed her PhD at the University of Guelph with Dr. Khursigara in the department of Molecular and Cellular Biology. Her project focussed on elucidating protein-protein interactions between the bacterial cell division proteins. Following completion of her PhD, Elyse accepted a post-doctoral fellowship at Karolinska Institute (Stockholm, Sweden) with Dr. Carsten Mim, in the research group of Dr. Hans Hebert. Here she learned high-end cryo-electron microscopic techniques and computational processing of large image datasets. Elyse then returned to Guelph and completed a 3-year post-doctoral fellowship in the Khursigara lab. In January 2021, she transitioned to a full-time position in the Molecular and Cellular Imaging Facility at the University of Guelph and continues to support various projects and collaborations in the Khursiagra lab. |
Elyse's Publications
Therapeutic stem cell-derived alveolar-like macrophages display bactericidal effects and resolve Pseudomonas aeruginosa-induced lung injury.
Bouch S, Litvack ML, Litman K, Luo L, Post A, Williston E, Park AJ, Roach EJ, Berezuk AM, Khursigara CM, Post M. J Cell Mol Med. 2022 May;26(10):3046-3059.
Pseudomonas aeruginosa membrane vesicles cause endothelial barrier failure and lung injury.
McVey MJ, Maishan M, Foley A, Turki R, Roach EJ, Deschler R, Weidenfeld S, Goldenberg NM, Khursigara CM, Kuebler WM. Eur Respir J. 2022 May 19;59(5):2101500.
The Next-Generation β-Lactamase Inhibitor Taniborbactam Restores the Morphological Effects of Cefepime in KPC-Producing Escherichia coli.
Roach EJ, Uehara T, Daigle DM, Six DA, Khursigara CM. Microbiol Spectr. 2021 Oct 31;9(2):e0091821.
Imaging host-pathogen interactions using epithelial and bacterial cell infection models.
Park AJ, Wright MA, Roach EJ, Khursigara CM. J Cell Sci. 2021 Feb 23;134(5)
Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster.
Whitfield GB, Marmont LS, Bundalovic-Torma C, Razvi E, Roach EJ, Khursigara CM, Parkinson J, Howell PL. PLoS Pathog. 2020 Apr 1;16(4):e1008281.
FtsA G50E mutant suppresses the essential requirement for FtsK during bacterial cell division in Escherichia coli.
Berezuk AM, Roach EJ, Seidel L, Lo RY, Khursigara CM. Can J Microbiol. 2020 Apr;66(4):313-327.
Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
Berezuk AM, Glavota S, Roach EJ, Goodyear MC, Krieger JR, Khursigara CM. Sci Rep. 2018 Aug 28;8(1):12933.
SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.
Di Paola M*, Park AJ*, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM. MBio. 2017 Dec 19;8(6).
*Co-authors.
Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling.
Roach EJ, Wroblewski C, Seidel L, Berezuk AM, Brewer D, Kimber MS, Khursigara CM. J Bacteriol. 2016 May 13;198(11):1683-93.
Crystal Structure and Site-Directed Mutational Analysis Reveals Key Residues Involved in Escherichia coli ZapA Function.
Roach EJ, Kimber MS, Khursigara CM. J Biol Chem. 2014 Aug 22;289(34):23276-86.
mEosFP-Based Green-to-Red Photoconvertible Subcellular Probes for Plants.
Mathur J, Radhamony R, Sinclair AM, Donoso A, Dunn N, Roach E, Radford D, Mohaghegh PS, Logan DC, Kokolic K, Mathur N. Plant Physiol. 2010 Dec;154(4):1573-87.
Therapeutic stem cell-derived alveolar-like macrophages display bactericidal effects and resolve Pseudomonas aeruginosa-induced lung injury.
Bouch S, Litvack ML, Litman K, Luo L, Post A, Williston E, Park AJ, Roach EJ, Berezuk AM, Khursigara CM, Post M. J Cell Mol Med. 2022 May;26(10):3046-3059.
Pseudomonas aeruginosa membrane vesicles cause endothelial barrier failure and lung injury.
McVey MJ, Maishan M, Foley A, Turki R, Roach EJ, Deschler R, Weidenfeld S, Goldenberg NM, Khursigara CM, Kuebler WM. Eur Respir J. 2022 May 19;59(5):2101500.
The Next-Generation β-Lactamase Inhibitor Taniborbactam Restores the Morphological Effects of Cefepime in KPC-Producing Escherichia coli.
Roach EJ, Uehara T, Daigle DM, Six DA, Khursigara CM. Microbiol Spectr. 2021 Oct 31;9(2):e0091821.
Imaging host-pathogen interactions using epithelial and bacterial cell infection models.
Park AJ, Wright MA, Roach EJ, Khursigara CM. J Cell Sci. 2021 Feb 23;134(5)
Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster.
Whitfield GB, Marmont LS, Bundalovic-Torma C, Razvi E, Roach EJ, Khursigara CM, Parkinson J, Howell PL. PLoS Pathog. 2020 Apr 1;16(4):e1008281.
FtsA G50E mutant suppresses the essential requirement for FtsK during bacterial cell division in Escherichia coli.
Berezuk AM, Roach EJ, Seidel L, Lo RY, Khursigara CM. Can J Microbiol. 2020 Apr;66(4):313-327.
Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
Berezuk AM, Glavota S, Roach EJ, Goodyear MC, Krieger JR, Khursigara CM. Sci Rep. 2018 Aug 28;8(1):12933.
SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.
Di Paola M*, Park AJ*, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM. MBio. 2017 Dec 19;8(6).
*Co-authors.
Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling.
Roach EJ, Wroblewski C, Seidel L, Berezuk AM, Brewer D, Kimber MS, Khursigara CM. J Bacteriol. 2016 May 13;198(11):1683-93.
Crystal Structure and Site-Directed Mutational Analysis Reveals Key Residues Involved in Escherichia coli ZapA Function.
Roach EJ, Kimber MS, Khursigara CM. J Biol Chem. 2014 Aug 22;289(34):23276-86.
mEosFP-Based Green-to-Red Photoconvertible Subcellular Probes for Plants.
Mathur J, Radhamony R, Sinclair AM, Donoso A, Dunn N, Roach E, Radford D, Mohaghegh PS, Logan DC, Kokolic K, Mathur N. Plant Physiol. 2010 Dec;154(4):1573-87.