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Elyse Roach, PhD
Elyse completed her PhD at the University of Guelph, with Dr. Khursigara in the department of Molecular and Cellular Biology. Her project focussed on elucidating the protein-protein interactions between the bacterial cytoskeletal protein FtsZ and several stabilizing proteins, known as FtsZ associated proteins (Zaps). Following completion of her PhD, Elyse accepted a post-doctoral fellowship at Karolinska Institute (Stockholm, Sweden) with Dr. Carsten Mim, in the research group of Dr. Hans Hebert. Here she learned high-end cryo-electron microscopic techniques and computational processing of large image datasets. Elyse is currently a post-doctoral researcher in the Khursigara lab. She uses a wide variety of molecular and microscopic techniques to investigate bacterial cell processes, antibiotic susceptibility, host-cell interactions and gross morphology for several projects and collaborations in Dr. Khursigara’s lab. |
Elyse's Publications
Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
Berezuk AM, Glavota S, Roach EJ, Goodyear MC, Krieger JR, Khursigara CM. Sci Rep. 2018 Aug 28;8(1):12933.
SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.
Di Paola M*, Park AJ*, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM. MBio. 2017 Dec 19;8(6).
*Co-authors.
Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling.
Roach EJ, Wroblewski C, Seidel L, Berezuk AM, Brewer D, Kimber MS, Khursigara CM. J Bacteriol. 2016 May 13;198(11):1683-93.
Crystal Structure and Site-Directed Mutational Analysis Reveals Key Residues Involved in Escherichia coli ZapA Function.
Roach EJ, Kimber MS, Khursigara CM. J Biol Chem. 2014 Aug 22;289(34):23276-86.
mEosFP-Based Green-to-Red Photoconvertible Subcellular Probes for Plants.
Mathur J, Radhamony R, Sinclair AM, Donoso A, Dunn N, Roach E, Radford D, Mohaghegh PS, Logan DC, Kokolic K, Mathur N. Plant Physiol. 2010 Dec;154(4):1573-87.
Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
Berezuk AM, Glavota S, Roach EJ, Goodyear MC, Krieger JR, Khursigara CM. Sci Rep. 2018 Aug 28;8(1):12933.
SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.
Di Paola M*, Park AJ*, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM. MBio. 2017 Dec 19;8(6).
*Co-authors.
Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling.
Roach EJ, Wroblewski C, Seidel L, Berezuk AM, Brewer D, Kimber MS, Khursigara CM. J Bacteriol. 2016 May 13;198(11):1683-93.
Crystal Structure and Site-Directed Mutational Analysis Reveals Key Residues Involved in Escherichia coli ZapA Function.
Roach EJ, Kimber MS, Khursigara CM. J Biol Chem. 2014 Aug 22;289(34):23276-86.
mEosFP-Based Green-to-Red Photoconvertible Subcellular Probes for Plants.
Mathur J, Radhamony R, Sinclair AM, Donoso A, Dunn N, Roach E, Radford D, Mohaghegh PS, Logan DC, Kokolic K, Mathur N. Plant Physiol. 2010 Dec;154(4):1573-87.