2020
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Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster.
Whitfield GB, Marmont LS, Bundalovic-Torma C, Razvi E, Roach EJ, Khursigara CM, Parkinson J, Howell PL. PLoS Pathog. 2020 Apr 1;16(4):e1008281. |
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Silver oxynitrate gel formulation for enhanced stability and antibiofilm efficacy.
Spina CJ, Notarandrea-Alfonzo J, Hay M, Ladhani R, Huszczynski S, Khursigara C, Precht R. Int J Pharm. 2020 Apr 30;580:119197. |
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FtsA G50E mutant suppresses the essential requirement for FtsK during bacterial cell division in Escherichia coli.
Berezuk AM, Roach EJ, Seidel L, Lo RY, Khursigara CM. Can J Microbiol. 2020 Apr;66(4):313-327. |
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Peptidoglycomics reveals compositional changes in peptidoglycan between biofilm- and planktonic-derived Pseudomonas aeruginosa
Anderson EM, Sychantha D, Brewer D, Clarke AJ, Geddes-McAlister J, Khursigara CM. J Biol Chem. 2020 Jan 10;295(2):504-516. |
2019
The Role of Pseudomonas aeruginosa Lipopolysaccharide in Bacterial Pathogenesis and Physiology
Huszczynski SM, Lam JS, Khursigara CM. Pathogens. 2019 Dec; 9(1).
Huszczynski SM, Lam JS, Khursigara CM. Pathogens. 2019 Dec; 9(1).
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Unique Regions of the Polysaccharide Co-Polymerase Wzz2 from Pseudomonas aeruginosa are Essential for O-Specific Antigen Chain Length Control.
Huszczynski SM, Coumoundouros C, Pham P, Lam JS, Khursigara CM. J Bacteriol. 2019 May 20. pii: JB.00165-19 |
2018
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Special issue "A Decade of Research Advancements in the Legacy of Terrance J. Beveridge - An Integrated View of Prokaryotic Life".
Koval SF, Khursigara CM. Can J Microbiol. 2018 Sep;64(9):vii-viii. |
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Inroads through the bacterial cell envelope: seeing is believing.
Khursigara CM, Koval SF, Moyles DM, Harris RJ. Can J Microbiol. 2018 Sep;64(9):601-617. |
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Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
Berezuk AM, Glavota S, Roach EJ, Goodyear MC, Krieger JR, Khursigara CM. Sci Rep. 2018 Aug 28;8(1):12933. |
2017
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The LPS Transport Pathway: A New Target for the Development of Gram-negative Antibiotics.
Berezuk AM, Khursigara CM. 2017. In Antibiotic Drug Discovery: New Targets and Molecular Entities (Firestine S, Lister T, eds.) Royal Society of Chemistry, Cambridge, UK |
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SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.
Di Paola M, Park AJ, Ahmadi S, Roach EJ, Wu YS, Struder-Kypke M, Lam JS, Bear CE, Khursigara CM. MBio. 2017 Dec 19;8(6). |
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Potentiation of Tobramycin by Silver Nanoparticles against Pseudomonas aeruginosa Biofilms.
Habash MB, Goodyear MC, Park AJ, Surette MD, Vis EC, Harris RJ, Khursigara CM. Antimicrob Agents Chemother. 2017 Oct 24;61(11). |
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Bypassing the Need for the Transcriptional Activator EarA through a Spontaneous Deletion in the BRE Portion of the fla Operon Promoter in Methanococcus maripaludis.
Ding Y, Berezuk A, Khursigara CM, Jarrell KF. Front Microbiol. 2017 Jul 17;8:1329. |
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A Genotypic Analysis of Five P. aeruginosa Strains after Biofilm Infection by Phages Targeting Different Cell Surface Receptors.
Pires DP, Dötsch A, Anderson EM, Hao Y, Khursigara CM, Lam JS, Sillankorva S, Azeredo J. Front Microbiol. 2017 Jun 30;8:1229. |
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Phylogenetic distribution of the euryarchaeal archaellum regulator EarA and complementation of a Methanococcus maripaludis ∆earA mutant with heterologous earA homologues.
Ding Y, Berezuk A, Khursigara CM, Jarrell KF. Microbiology. 2017 May 23. |
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Complementation of an aglB Mutant of Methanococcus maripaludis with Heterologous Oligosaccharyltransferases.
Ding Y, Vrionis HA, Schneider J, Berezuk A, Khursigara CM, Jarrell KF. PLoS One. 2016 Dec 1;11(12):e0167611. |
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Identification of the First Transcriptional Activator of an Archaellum Operon in a Euryarchaeon.
Ding Y, Nash J, Berezuk A, Khursigara CM, Langelaan DN, Smith SP, Jarrell KF. Mol Microbiol. 2016 Oct;102(1):54-70. |
2016
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Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling.
Roach EJ, Wroblewski C, Seidel L, Berezuk AM, Brewer D, Kimber MS, Khursigara CM. J Bacteriol. 2016 May 13;198(11):1683-93. |
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Survival Proteomes: The Emerging Proteotype of Antimicrobial Resistance.
Park AJ, Krieger JR, Khursigara CM. FEMS Microbiol Rev. 2016 May;40(3):323-42. |
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Effects of Growth Conditions on Archaellation and N-glycosylation in Methanococcus maripaludis.
Ding Y, Lau Z, Logan SM, Kelly JF, Berezuk A, Khursigara CM, Jarrell KF. Microbiology. 2016 Feb;162(2):339-50. |
2015
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Tracking the Dynamic Relationship between Cellular Systems and Extracellular Subproteomes in Pseudomonas aeruginosa Biofilms.
Park AJ, Murphy K, Surette MD, Bandoro C, Krieger JR, Taylor P, Khursigara CM. J Proteome Res. 2015 Nov 6;14(11):4524-37. |
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Visualizing and Quantifying Pseudomonas aeruginosa Infection in the Hindbrain Ventricle of Zebrafish Using Confocal Laser Scanning Microscopy.
Rocker AJ, Weiss AR, Lam JS, Van Raay TJ, Khursigara CM. J Microbiol Methods. 2015 Oct;117:85-94. |
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Single-Nucleotide Polymorphisms Found in the migA and wbpX Glycosyltransferase Genes Account for the Intrinsic Lipopolysaccharide Defects Exhibited by Pseudomonas aeruginosa PA14.
Hao Y, Murphy K, Lo RY, Khursigara CM, Lam JS. J Bacteriol. 2015 Sep;197(17):2780-91. |
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Effects of N-glycosylation Site Removal in Archaellins on the Assembly and Function of Archaella in Methanococcus maripaludis.
Ding Y, Uchida K, Aizawa S, Murphy K, Berezuk A, Khursigara CM, Chong JP, Jarrell KF. PLoS One. 2015 Feb 20;10(2):e0116402. |
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Simulating Distal Gut Mucosal and Luminal Communities Using Packed-Column Biofilm Reactors and an In Vitro Chemostat Model.
McDonald JA, Fuentes S, Schroeter K, Heikamp-deJong I, Khursigara CM, de Vos WM, Allen-Vercoe E. J Microbiol Methods. 2015 Jan;108:36-44. |
2014
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Antimicrobial Targets Localize to the Extracellular Vesicle-Associated Proteome of Pseudomonas aeruginosa Grown in a Biofilm.
Park AJ, Surette MD, Khursigara CM. Front Microbiol. 2014 Sep 3;5:464. |
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Synergy of Silver Nanoparticles and Aztreonam Against Pseudomonas aeruginosa PAO1 Biofilms.
Habash MB, Park AJ, Vis EC, Harris RJ, Khursigara CM. Antimicrob Agents Chemother. 2014 Oct;58(10):5818-30. |
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Site-Directed Fluorescence Labeling Reveals a Revised N-terminal Membrane Topology and Functional Periplasmic Residues in the Escherichia coli Cell Division Protein FtsK.
Berezuk AM, Goodyear M, Khursigara CM. J Biol Chem. 2014 Aug 22;289(34):23287-301. |
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Crystal Structure and Site-Directed Mutational Analysis Reveals Key Residues Involved in Escherichia coli ZapA Function.
Roach EJ, Kimber MS, Khursigara CM. J Biol Chem. 2014 Aug 22;289(34):23276-86. |
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A Temporal Examination of the Planktonic and Biofilm Proteome of Whole Cell Pseudomonas aeruginosa PAO1 Using Quantitative Mass Spectrometry.
Park AJ, Murphy K, Krieger JR, Brewer D, Taylor P, Habash M, Khursigara CM. Mol Cell Proteomics. 2014 Apr;13(4):1095-105. |
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Influence of O Polysaccharides on Biofilm Development and Outer Membrane Vesicle Biogenesis in Pseudomonas aeruginosa PAO1.
Murphy K, Park AJ, Hao Y, Brewer D, Lam JS, Khursigara CM. J Bacteriol. 2014 Apr;196(7):1306-17. |
2013 and Earlier
Evaluation of Microbial Community Reproducibility, Stability and Composition in a Human Distal Gut Chemostat Model.
McDonald JA, Schroeter K, Fuentes S, Heikamp-Dejong I, Khursigara CM, de Vos WM, Allen-Vercoe E.
J Microbiol Methods. 2013 Nov;95(2):167-74.
The Effect of Milk Fat Globules on Adherence and Internalization of Salmonella enteritidis to HT-29 cells.
Guri A, Griffiths M, Khursigara CM, Corredig M.
J Dairy Sci. 2012 Dec;95(12):6937-45.
Lateral Density of Receptor Arrays in the Membrane Plane Influences Sensitivity of the E. coli Chemotaxis Response.
Khursigara CM, Lan G, Neumann S, Wu X, Ravindran S, Borgnia MJ, Sourjik V, Milne J, Tu Y, Subramaniam S.
EMBO J. 2011 May 4;30(9):1719-29.
Chemotaxis Kinase CheA is Activated by Three Neighbouring Chemoreceptor Dimers as Effectively as by Receptor Clusters.
Li M, Khursigara CM, Subramaniam S, Hazelbauer GL.
Mol Microbiol. 2011 Feb;79(3):677-85.
Role of HAMP Domains in Chemotaxis Signaling by Bacterial Chemoreceptors.
Khursigara CM, Wu X, Zhang P, Lefman J, Subramaniam S.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16555-60.
Chemoreceptors in Caulobacter crescentus: Trimers of Receptor Dimers in a Partially Ordered Hexagonally Packed Array.
Khursigara CM, Wu X, Subramaniam S.
J Bacteriol. 2008 Oct;190(20):6805-10.
Direct Visualization of Escherichia coli Chemotaxis Receptor Arrays Using Cryo-Electron Microscopy.
Zhang P, Khursigara CM, Hartnell LM, Subramaniam S.
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3777-81.
Structure of TonB in Complex with FhuA, E. coli Outer Membrane Receptor.
Pawelek PD, Croteau N, Ng-Thow-Hing C, Khursigara CM, Moiseeva N, Allaire M, Coulton JW.
Science. 2006 Jun 2;312(5778):1399-402.
Deletion of the Proline-Rich Region of TonB Disrupts Formation of a 2:1 Complex with FhuA, an Outer Membrane Receptor of Escherichia coli.
Khursigara CM, De Crescenzo G, Pawelek PD, Coulton JW.
Protein Sci. 2005 May;14(5):1266-73.
Kinetic Analyses Reveal Multiple Steps in Forming TonB-FhuA Complexes from Escherichia coli.
Khursigara CM, De Crescenzo G, Pawelek PD, Coulton JW.
Biochemistry. 2005 Mar 8;44(9):3441-53.
Enhanced Binding of TonB to a Ligand-Loaded Outer Membrane Receptor: Role of the Oligomeric State of TonB in Formation of a Functional FhuA.TonB Complex.
Khursigara CM, De Crescenzo G, Pawelek PD, Coulton JW.
J Biol Chem. 2004 Feb 27;279(9):7405-12.
Enteropathogenic Escherichia coli Virulence Factor Bundle-Forming Pilus has a Binding Specificity for Phosphatidylethanolamine.
Khursigara C, Abul-Milh M, Lau B, Girón JA, Lingwood CA, Barnett Foster DE.
Infect Immun. 2001 Nov;69(11):6573-9.
McDonald JA, Schroeter K, Fuentes S, Heikamp-Dejong I, Khursigara CM, de Vos WM, Allen-Vercoe E.
J Microbiol Methods. 2013 Nov;95(2):167-74.
The Effect of Milk Fat Globules on Adherence and Internalization of Salmonella enteritidis to HT-29 cells.
Guri A, Griffiths M, Khursigara CM, Corredig M.
J Dairy Sci. 2012 Dec;95(12):6937-45.
Lateral Density of Receptor Arrays in the Membrane Plane Influences Sensitivity of the E. coli Chemotaxis Response.
Khursigara CM, Lan G, Neumann S, Wu X, Ravindran S, Borgnia MJ, Sourjik V, Milne J, Tu Y, Subramaniam S.
EMBO J. 2011 May 4;30(9):1719-29.
Chemotaxis Kinase CheA is Activated by Three Neighbouring Chemoreceptor Dimers as Effectively as by Receptor Clusters.
Li M, Khursigara CM, Subramaniam S, Hazelbauer GL.
Mol Microbiol. 2011 Feb;79(3):677-85.
Role of HAMP Domains in Chemotaxis Signaling by Bacterial Chemoreceptors.
Khursigara CM, Wu X, Zhang P, Lefman J, Subramaniam S.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16555-60.
Chemoreceptors in Caulobacter crescentus: Trimers of Receptor Dimers in a Partially Ordered Hexagonally Packed Array.
Khursigara CM, Wu X, Subramaniam S.
J Bacteriol. 2008 Oct;190(20):6805-10.
Direct Visualization of Escherichia coli Chemotaxis Receptor Arrays Using Cryo-Electron Microscopy.
Zhang P, Khursigara CM, Hartnell LM, Subramaniam S.
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3777-81.
Structure of TonB in Complex with FhuA, E. coli Outer Membrane Receptor.
Pawelek PD, Croteau N, Ng-Thow-Hing C, Khursigara CM, Moiseeva N, Allaire M, Coulton JW.
Science. 2006 Jun 2;312(5778):1399-402.
Deletion of the Proline-Rich Region of TonB Disrupts Formation of a 2:1 Complex with FhuA, an Outer Membrane Receptor of Escherichia coli.
Khursigara CM, De Crescenzo G, Pawelek PD, Coulton JW.
Protein Sci. 2005 May;14(5):1266-73.
Kinetic Analyses Reveal Multiple Steps in Forming TonB-FhuA Complexes from Escherichia coli.
Khursigara CM, De Crescenzo G, Pawelek PD, Coulton JW.
Biochemistry. 2005 Mar 8;44(9):3441-53.
Enhanced Binding of TonB to a Ligand-Loaded Outer Membrane Receptor: Role of the Oligomeric State of TonB in Formation of a Functional FhuA.TonB Complex.
Khursigara CM, De Crescenzo G, Pawelek PD, Coulton JW.
J Biol Chem. 2004 Feb 27;279(9):7405-12.
Enteropathogenic Escherichia coli Virulence Factor Bundle-Forming Pilus has a Binding Specificity for Phosphatidylethanolamine.
Khursigara C, Abul-Milh M, Lau B, Girón JA, Lingwood CA, Barnett Foster DE.
Infect Immun. 2001 Nov;69(11):6573-9.