Contact Steven
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Steven Huszczynski, PhD
Steven’s project is aimed at elucidating the antimicrobial mechanisms of silver oxynitrate. Silver has been used as an antimicrobial for centuries and is thought to target numerous cellular components, resulting in cessation of cellular respiration and cell death. The majority of mechanistic studies to date have utilized singly ionic silver; however, higher oxidation state silver (Ag2+ and Ag3+), as found in silver oxynitrate, possesses more potent and efficient antimicrobial properties. Steven will use a multi-faceted approach to determine what toxic effect(s) higher oxidation states of silver unleash unto bacterial cells. |
Steven's Publications
Unique Regions of the Polysaccharide Co-Polymerase Wzz2 from Pseudomonas aeruginosa are Essential for O-Specific Antigen Chain Length Control.
Huszczynski SM, Coumoundouros C, Pham P, Lam JS, Khursigara CM. J Bacteriol. 2019 May 20. pii: JB.00165-19
A Bacteriophage-Acquired O-Antigen Polymerase (Wzyβ) from P. aeruginosa Serotype O16 Performs a Varied Mechanism Compared to Its Cognate Wzyα.
Taylor VL, Hoage JF, Thrane SW, Huszczynski SM, Jelsbak L, Lam JS. Front Microbiol. 2016 Mar 31;7:393
Membrane Translocation and Assembly of Sugar Polymer Precursors.
Taylor VL, Huszczynski SM, Lam JS. Curr Top Microbiol Immunol. 2017;404:95-128.
Conserved-residue mutations in Wzy affect O-antigen polymerization and Wzz-mediated chain-length regulation in Pseudomonas aeruginosa PAO1.
Islam ST, Huszczynski SM, Nugent T, Gold AC, Lam JS. Sci Rep. 2013 Dec 6;3:3441
Five new genes are important for common polysaccharide antigen biosynthesis in Pseudomonas aeruginosa.
Hao Y, King JD, Huszczynski S, Kocíncová D, Lam JS. MBio. 2013 Jan 22;4(1):e00631-12.
Unique Regions of the Polysaccharide Co-Polymerase Wzz2 from Pseudomonas aeruginosa are Essential for O-Specific Antigen Chain Length Control.
Huszczynski SM, Coumoundouros C, Pham P, Lam JS, Khursigara CM. J Bacteriol. 2019 May 20. pii: JB.00165-19
A Bacteriophage-Acquired O-Antigen Polymerase (Wzyβ) from P. aeruginosa Serotype O16 Performs a Varied Mechanism Compared to Its Cognate Wzyα.
Taylor VL, Hoage JF, Thrane SW, Huszczynski SM, Jelsbak L, Lam JS. Front Microbiol. 2016 Mar 31;7:393
Membrane Translocation and Assembly of Sugar Polymer Precursors.
Taylor VL, Huszczynski SM, Lam JS. Curr Top Microbiol Immunol. 2017;404:95-128.
Conserved-residue mutations in Wzy affect O-antigen polymerization and Wzz-mediated chain-length regulation in Pseudomonas aeruginosa PAO1.
Islam ST, Huszczynski SM, Nugent T, Gold AC, Lam JS. Sci Rep. 2013 Dec 6;3:3441
Five new genes are important for common polysaccharide antigen biosynthesis in Pseudomonas aeruginosa.
Hao Y, King JD, Huszczynski S, Kocíncová D, Lam JS. MBio. 2013 Jan 22;4(1):e00631-12.